【摘要】 用L-脯氨酸催化α-酮酰胺与甲基酮的不对称直接Aldol反应,获得了不同光学活性的α-羟基酰胺,产率在21%～99%之间,对映选择性最高达到43%ee.加成产物的结构用元素分析、红外光谱和核磁共振进行了表征.更多还原

【Abstract】 Direct asymmetric aldol addition of methyl ketones to α-ketoamides was achieved using L-proline as a chiral catalyst. Various optically active α-hydroxyamides were obtained in variable yields (21%～99%) with enantioselectivity up to 43% ee. The structures of the adducts were confirmed by ele- mental analysis, IR, 1H NMR and 13C NMR spectra.更多还原