【摘要】 目的探讨肿瘤转移抑制基因(nm23-H1)在晚期食管癌中表达与化疗敏感性的关系。方法应用免疫组化分析方法,检测57例食管癌患者nm23-H1表达,以铂类为主化疗至少2个疗程后进行化疗效果评价。结果nm23-H1阳性率为42.1%,与食管癌的临床组织分级有关,而与淋巴结转移、性别、年龄、位置及细胞分化无关;nm23-H1(+)的患者,其化疗敏感性明显优于nm23-H1(-)患者。结论晚期食管癌患者中,恶性度越高,nm23-H1表达越高。nm23-H1提示术后以铂类药物为主的化疗敏感性。更多还原

【Abstract】 Objective To explore the relationship of expression of nm23-H1,considered to be an non-metastasis gene,with the sensitivity of chemotherapy in patients with advanced esophagus carcinoma.Methods The expression of nm23-H1 was measured by immunohistochemistry in 57 patients with advanced esophagus carcinoma.The cisplatin-based chemotherapy was given at least two cycles,then the effect of chemotherapy was evaluated.Results Nm23-H1 expression was detected in 42.1%(24/57)of the pathological sections,which was positively correlated with tumor stage(P<0.05),and negatively correlated with lymph node metastasis,sexuality,age,position and cell differentiation.The sensitivity of chemotherapy of nm23-H1 positive group was statistically superior to that of nm23-H1 negative group(P<0.01).Conclusion In advanced esophagus carcinoma,the higher malignant degree,the more expression of nm23-H1.Nm23-H1 expression level could predict cisplatin-based chemotherapy effect in esophagus carcinoma patients after operation.更多还原