【摘要】 目的探讨化疗联合重组人白细胞介素11(rhIL-11)和粒细胞集落刺激因子(G-CSF)用于自体外周血造血干细胞移植(APBSCT)动员的可行性和有效性。方法5例恶性血液病患者(估计动员效果差)使用化疗药物24～48h后接受rhIL-11(25μg.kg-1.d-1)和G-CSF(10μg.kg-1.d-1)皮下注射直至干细胞采集结束。观察应用rhIL-11后的动员效果、不良反应及移植后造血重建、并发症和临床转归。结果患者耐受良好,动员后(1.40±0.55)次干细胞采集可获足量CD34+细胞。移植后9～11d内达到造血重建,血小板低于20×109/L时间为0～1d,无出血表现。随访(28.8±8.58)个月,2例分别于移植后8、10个月复发,2例持续完全缓解,1例病情稳定。结论化疗联合rhIL-11和G-CSF方案具有良好的动员效果,且血小板重建迅速。更多还原

【Abstract】 Objective To explore the feasibility and effectiveness of mobilization with high-dose chemotherapy followed by recombinant human interleukin-11(rhIL-11)plus granulocyte colony-stimulating factor(G-CSF)in autologous peripheral blood stem-cell transplantation(APBSCT).Methods Five patients with hematological malignancies received high-dose chemotherapy,and 24～48 h after completion of chemotherapy were given daily subcutaneous injections of G-CSF(10 μg·kg-1·d-1)and rhIL-11(25 μg·kg-1·d-1)until the completion of peripheral stem cell apheresis.The adverse effects of rhIL-11 and the effect of mobilization were observed.Hematopoietic reconstitution,complications and clinical outcome after transplantation were observed as well.ResultsThe use of rhIL-11 was tolerated well by each patient.Adequate number of CD34+ cells was obtained after 1.40±0.55 apheresis collections in all cases.The time reaching hematopoietic reconstitution was 90 to 11 days.Each patient had a temporary fever during agranulocytosis.The time for platelet count<20×109/L was 0 to 2 days.None of them had bleeding complications.All patients have been followed up for(28.8±8.58)months after transplantation,with complete remission in 2 cases,in steady condition in 1 case,and recurrence in 8 and 10 months later,respectively.Conclusion The regimen of chemotherapy/IL-11 plus G-CSF is successful in mobilizing adequate numbers of CD34+ cells,and the reconstruction of platelet is rapid.更多还原