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72例中药引起药物性肝损的临床研究

An analysis of 72 cases with liver disease caused by traditional Chinese medicine

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【作者】 陆玮婷李军欧宁刘源郭雪江王杰鲁翔黄峻

【Author】 LU Weiting, LI Jun, OU Ning,et al.Department of Infectious Diseases, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, CHINA

【机构】 南京医科大学第一附属医院感染病科南京医科大学第一附属医院感染病科

【摘要】 目的探讨中药引起的肝损,以提高临床医师对药物性肝损的认识。方法选取我院72例中药药物性肝损病例,分析其临床表现、肝损的类型、程度和转归等特点。结果72例药物性肝损中,胆汁瘀积型26例,占37.1%;肝细胞型25例,占35.8%;混合型19例,占27.1%(2例因ALP数据缺失,未予分型)。引起的肝损程度以轻度~中度异常为主。治愈好转率为88.9%,病死率为6.9%。结论中药引起的肝损临床表现无特异性,临床医师用药期应注意监测肝功能。

【Abstract】 Objective To analyze the clinical features of liver disease caused by traditional Chinese medicine. Methods The characteristics of 72 patients with drug-induced liver damage were retrospectively analyzed.Results Of 72 cases,25 patients(35.8%) were classified as hepatocellular, 26 patients(37.1%) as cholestatic injury,and 19 patients(27.1%) as mixed hepatitis. 88.9% of the cases were cured or relieved, while the mortality was 6.9%. Conclusion Liver disease caused by traditional Chinese medicine is of no specificity.The liver functions should be monitored during takening traditional Chinese medicine.

【基金】 江苏省科协社会发展计划(BS2004004)
  • 【文献出处】 江苏医药 ,Jiangsu Medical Journal , 编辑部邮箱 ,2007年06期
  • 【分类号】R28;R595.3
  • 【被引频次】10
  • 【下载频次】518
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