【摘要】 目的观察长期强化降糖治疗对老年2型糖尿病患者骨密度及骨折发生率的影响。方法将96例老年2型糖尿病患者分为强化降糖治疗组和对照组,治疗3年,治疗前后测体重指数、空腹血糖、糖化血红蛋白、骨密度。结果①两组的腰椎和髋骨骨密度与年龄、病程、体重指数相关(P<0.05),与空腹血糖、糖化血红蛋白相关性无统计学意义(P>0.05)。②3年后,两组男女的腰髋部骨密度均下降(P<0.05)。③男性患者中对照组腰椎骨密度下降速度快于强化降糖治疗组(P<0.05)。女性患者中组间差异无统计学意义;对照组中有2名患者发生非暴力性股骨颈骨折,强化降糖治疗组无骨折病例。结论血糖水平可能是通过影响骨质量来影响骨强度。强化降糖治疗有利于延缓老年2型糖尿病患者骨强度降低,预防骨折的发生。更多还原

【Abstract】 Objective To investigate the influence of long-term intensification therapy on bone mineral density(BMD)of elderly with type 2 diabetes mellitus(DM). Methods 96 patients were divided into intensification and control groups randomly, Body mass index(BMI),fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c),BMD at lumbar spine (L1-L4) and hip( neck, trochanter and Ward’s triangle of femur ) was measured in all patients before treatment and after 3 years of follow-up. Results ① BMD at lumbar spine and hip was significantly correlated with age,disease duration and BMI(P<0.05),but not correlated with FBG or HbA1c. ② BMD at lumbar spine and hip both decreased continually. ③ BMD at lumbar spine of male patients in intensification group decreased slower than that of control group (P<0.05). No difference was found in other groups or sites; 2 patients of control group subjected nonviolent femoral neck fracture during 3 years of follow-up, while none was found in intensification therapy group. Conclusion Long-term intensification therapy can ameliorate bone strength and degrade the risk of fracture.更多还原