【摘要】 目的观察益肾复方对大鼠阿霉素肾病的作用。方法采用静脉注射阿霉素(5.5mg/kg)造成大鼠实验性肾病模型,观察益肾复方灌胃给药7周对肾病大鼠血液生化学指标及病理组织学的影响。结果肾病模型组大鼠尿蛋白排出增加,血清尿素氮(BUN)、甘油三酯(TG)和总胆固醇(TCH)含量升高,总蛋白(TP)和白蛋白(ALB)含量降低。益肾复方(30、60g/kg.d)可升高肾病大鼠TP和ALB含量,降低肾病大鼠TG和TCH含量,益肾复方60g/kg.d可改善肾病大鼠病理组织学变化。结论益肾复方对大鼠阿霉素肾病有一定的保护作用。更多还原

【Abstract】 Objective To observe the protective effects of YiShenFuFang on ADR-induced nephropathy in rats.Methods Nephrotic syndrome was induced by adriamycin(ADR 5.5 mg/kg), YishenFuFang (15,30,60 g/kg·d ) intragastric administric seven weeks,Urinary protein excretion,blood biochermical parameters and the pathology changes of renal were observed. Results Compared with normal groups, the urinary protein excretion ,serum BUN,TG and TCH increased ,serum TP and ALB reduced in model group.YiShenFuFang(30,60 g/kg·d)could reduce urinary protein excrection, serum TG and TCH, raised serum TP and ALB. In addition,YishenFuFang (60 g/kg·d)could ameliorate pathological changes of kindey. Conclusion YiShenFuFang (30,60g/kg·d) has protective effects on ADR nephrotic syndrome of rat.更多还原