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鸡SNP多样性的比较研究与群体有效规模的估算

Comparative study of SNP diversity and calculation of the effective size of population in chicken

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【作者】 饶友生王樟凤周敏沈栩夏梦娜张细权

【Author】 RAO You-Sheng 1,2,WANG Zhang-Feng2,ZHOU Min1,2,SHEN Xu1,XIA Meng-Na1 ZHANG Xi-Quan1 1. College of Animal Science,South China Agricultural University,Guangzhou 510642,China; 2. Biotechnology Institute,JiangXi Education College,Nanchang 330029,China

【机构】 华南农业大学动物科学学院江西教育学院生物技术研究所华南农业大学动物科学学院 广州510642 江西教育学院生物技术研究所南昌330029南昌330029广州510642 江西教育学院生物技术研究所南昌330029广州510642

【摘要】 以红色原鸡(Red Jungle Fowl,RJF)、丝羽乌骨鸡(Taihe silk Chicken,TS)、隐性白洛克鸡(White Recessive Rock,WRR)为资源群,在鸡一号染色体的Contig.060226.1上选取了一个200kb的区域,比较研究了3个群体的SNP(single nucleotide polymorphism)多样性、估算了鸡的初始群体有效规模大小(effective size of population,Ne)。红色原鸡、丝羽乌骨鸡、隐性白洛克鸡3个群体的平均杂合度分别为0.28533±0.03475、0.32926±0.03919、0.30168±0.04038。显著性检验差异不显著(P=0.2368>0.05)。根据Latter和Nei的方法对鸡的群体有效规模进行了估算,鸡的初始群体有效规模大小为20000~150000。鸡在驯养的早期阶段经历过严厉的瓶颈效应,但瓶颈效应对鸡各品种SNP的多样性并未产生显著影响。笔者认为,鸡在驯养的早期阶段群体有效规模足够大,品种分化过程中群体迅速扩张,品种间的广泛杂交(特别是和红色原鸡之间)以及鸡基因组的高重组率等因素是导致家鸡和原鸡以及各家鸡品种间SNP多样性没有显著差别的重要原因。

【Abstract】 A region (200 kb) of Contig. 060226.1 on GGA1 was selected to study the average diversity of Red Jungle Fowl (RJF),Taihe Silk chicken (TS),and White Recessive Rock (WRR),and estimate the effective population size (Ne) of chicken. The mean heterozygosities of RJF,TS and WRR were 0.28533±0.034747,0.32926±0.039191 and 0.30168± 0.040382,respectively. Significant test indicted that there is not significant difference between them (P=0.2368>0.05). The initial chicken effective population size was estimated to be about 20 000?150 000. Chicken has undergone serious popula-tion bottleneck effect during the first stage of domestication. However,this bottleneck effect did not result in a substantial loss of diversity as revealed by SNP. The possible explanations for similar SNP diversity between domesticated chicken and Red Jungle Fowl might due to many factors,such as a big Ne in earlier phase of domestication,population expending in breed differentiation,abroad crossing between breeds (especially crossing with RJF),together with high recombination rate in chicken genome.

【关键词】 SNP多样性群体有效规模
【Key words】 chickenSNPdiversityeffective size of population
【基金】 国家重点基础研究发展规划(973计划)项目(编号:2006CB102100)资助~~
  • 【分类号】S831;Q953
  • 【被引频次】8
  • 【下载频次】384
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