【摘要】 目的研究超微三七饮片中皂苷的溶出动力学与溶出特性。方法采用紫外-可见分光光度法,以皂苷为溶出指标,测定不同粒度超微三七饮片中皂苷的溶出速率,根据扩散理论推断溶出动力学方程,然后将溶出速率实验得到的数据进行回归分析,并与动力学方程进行对比,考察超微三七饮片中皂苷的溶出特性。结果超微三七饮片在一定的粒度范围内,皂苷按一级动力学方程溶出,当颗粒粒度d50达到8.00μm时,不符合一级动力学模型,表现出了快速释放的溶出特性。结论三七饮片经过适度的超微细可以明显改善皂苷的溶出效果。更多还原

【Abstract】 Objective To study the dissolving-out kinetics and characteristics of Total Saponins in Superfine Radix notoginseng.Methods The dissolution rate of total saponins from superfine Radix notoginseng with different particle size was determined by UV,and then the resolution rate data were collected and analyzed recursively.The recursive results were compared with the kinetics equation inferred by Fick,s theory to investigate the dissolution characteristics.Results The total saponins of superfine Radix notoginseng within definite particle size are dissolved according to one-level kinetics equation.When the particle size(d50) is 8.00μm,the dissolution of total saponins is not linear with the kinetics equation,and its characteristics obviously changed.Conclusion The dissolution effect was obviously improved after Radix notoginseng was superfinely pulverized to moderate particle size.更多还原