【摘要】 目的观察细胞病理学对桥本病的诊断意义,评价甲状腺局部免疫调节治疗桥本病的疗效。方法对临床、血清学和超声诊断为桥本病的患者行细针针吸细胞病理学诊断。确诊的92例患者分3组:A组31例口服药物治疗;B组31例口服药物加局部免疫调节治疗;C组30例局部免疫调节治疗。结果92例细胞病理学诊断:淋巴细胞型54例,嗜酸性变型21例,上皮破坏型13例,纤维化型5例。3组甲状腺体积缩小,质地变软,血清学恢复和淋巴细胞浸润减轻明显改善;治疗后显示:B、C两组与A组之间比较有显著性差异,B、C组之间比较差异无显著性,B组疗效最佳,C组次之。结论细针针吸细胞病理学诊断桥本病客观、准确、特异。地塞米松局部注射治疗桥本病疗效显著。更多还原

【Abstract】 Objective To comment on the significance of cytopathologic diagnosis of Hashimoto’s thyroiditis(HT) and evaluate the curative effect of local immunity regulation for its treatment.Methods 92 patients with HT diagnosed clinically,by serology and ultrasonography,and especially,by fine-needle aspiration biopsy,were divided into 3 groups to undergo varied regimens of treatment.Group A,the control,was treated with conventional oral drugs;group B,with oral drugs plus local injection of dexamethasone;group C,with local dexamethasone alone.The injection was given once a week,5 weeks as a course,which was repeated 2 times at 2-month intervals.The efficacy was assessed by comparing the biochemical,ultrasonic and cytological findings before and after the treatment.Results The curative effects were significantly better in groups B and C than in group A(P<0.05),with that in group B as the best,although the difference in effects was insignificant between groups B and C.Conclusion The exfoliative and aspiration cytopathology for diagnosing HT is objective,accurate and specific.Local dexamethasone immunity regulation therapy for HT is obviously efficacious.更多还原