【摘要】 目的:研究乳腺癌中是否存在血管生成拟态(VM),及其与基质金属蛋白酶(MMP-2)表达及预后的关系。方法:选取乳腺癌石蜡标本180例,进行PAS和CD34双重染色,观察是否存在VM;然后对存在VM者和对照组进行MMP-2染色、乳腺癌微血管密度(MVD)计数以及随访,并比较他们之间的相互关系。结果:9例标本中存在VM。VM组的生存率和MVD值明显低于无血管生成VM组。而VM组的MMP-2值明显高于无VM组。结论:乳腺癌中存在VM,可能是高度恶性生物学行为的基础之一。更多还原

【Abstract】 Objective: To study whether there was vasculogenic mimicry(VM) in breast cancer and its relationship with microvessel density(MVD),MMP-2 expression and prognosis. Methods:180 paraffin specimens of breast cancer were chosen to perform double staining of PAS and CD34 and VM were observed. And then specimens existing VM and the controls were performed MMP-2 staining and MVD counting, and the patients from whom the specimens were obtained were followed up. The relationship of breast cancer VM with MVD, MMP-2 expression and prognosis were compared. Results:9 specimens were found existing VM. The survival rate and MVD of the VM group were obviously lower than those of the non-VM group. And the MMP-2 expression of VM group was significantly higher than that of non-VM group. Conclusion:VM might be one of the foundations of its highly malignant biological behavior.更多还原