【摘要】 目的:探讨坦索罗辛治疗慢性盆底痛综合征(CPPS)的有效性及安全性。方法:随机双盲对照研究,50例患者随机分为坦索罗辛组22例(0.2mg每晚1次),安慰剂对照组28例。分别在治疗开始、2周、4周、12周,治疗结束4周、8周、12周观察患者CPSI评分。结果:50例患者完成研究,治疗12周后,坦索罗辛组CPSI评分较对照组有显著的下降(分别是3.5,9.8,P<0.01);疼痛评分较对照组有显著改善(分别是1.7,6.0,P<0.01);总有效率显著高于对照组(分别是78.2%,25.1%)。在治疗结束后12周,坦索罗辛组的CPSI评分较治疗结束时有所升高,而对照组没有显著的变化(与治疗前比较CPSI总分下降分别是4.4,1.7)。结论:坦索罗辛治疗CPPS是安全、有效的,可以显著的改善患者的疼痛症状,但远期疗效不理想。更多还原

【Abstract】 Objective:To investigate the efficacy and safety of tamsulosin in the treatment of chronic pelvic pain syndrome(CPPS).Methods:With a prospctive,randomized,double-blind,placebo-controlled study,50 patients with CPPS,who did not receive other alpha-blocker previously,were enrolled in this study,and divided into two groups in random.22 cases in the treatment group(tamsulosin group) were treated with tamsulosin 0.2 mg once every night,while 28 cases in the control group only with placebo.The score of chronic prostatitis symptom index(CPSI) of the patients in both groups was observed at the beginning of treatment and 2,4 and 12 week after treatment as well as 4,8 and 12 weeks after the end of treatment respectively.Results:After 12 weeks of treatment,the tamsulosin group had a statistically significant decrease in total CPSI score compared with the control group (3.5 and 9.8 respectively,P<0.01),especially in the pain score(1.7 and 6.0 respectively,P<0.01).The total effective rate in the tamsulosin group was 78.2%,significantly higher than 25.1% in the control group.12 weeks after treatment ended,the score of CPSI in the tamsulosin group had a obvious decrease compared with that at the end of treatment,while without obvious change in the control group(compared with that before the treatment,the decrease in the score of CPSI was 4.4 and 1.7 respectively).Conclusion:Tamsulosin is safe and effective in the treatment of CPPS,and can significantly improve the pain symptom of these patients,but its late result is discouraging.更多还原