【摘要】 目的:观测慢性阻塞性肺病(COPD)患者诱导痰中血管内皮生长因子(VEGF)的水平。方法:采用ELISA法分别检测COPD急性加重期50例,COPD稳定期30例和健康对照组20例诱导痰中VEGF水平,并同时测第1秒钟用力呼气容积占预计值的百分比(FEV1%)和第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC)。结果:COPD急性加重期诱导痰中的VEFG(3945.06±1207.09)pg/ml较健康对照组(2140.63±1091.71)pg/ml明显升高,P<0.001。COPD稳定期VEGF(455.64±260.18)pg/ml,较健康对照组和COPD急性加重期组明显较低(P<0.001)。结论:VEGF可能影响COPD的发病机制,且也可作为COPD急性加重的判断指标之一。更多还原

【Abstract】 Objective:To observe the level of vascular endothelial growth factor(VEGF) in induced sputum of patients with chronic obstructive pulmonary disease(COPD).Methods:Fifty patients with mild chronic obstructive pulmonary disease,thirty patients with moderate chronic obstructive pulmomary disease and 20 mormal controls were included in this study.The concentration of VEGF in induced sputum and the correlations between VEGF levels and pulmonary function were examined.Results:The mean concentration of VEGF in induced sputum was significantly higher in patients with acute COPD(3 945.06±1 207.09)pg/ml than in normal controls(2 140.63±1 091.71) pg/ml,P<0.001 but significantly lower in patients with stable COPD(455.64±260.18)pg/ml.Conclusion:Our findings suggest that VEGF may affect the pathogenesis of COPD and may be a important index to judge of acute aggravation phase of COPD.更多还原