【摘要】 目的研究2-硫嘧啶S上烷基取代反应。方法以2-硫嘧啶为原料,分别采用K2CO3方法和CH3ONa-CH3OH方法,合成了2位硫烷基取代产物。采用1H NMR,IR,质谱鉴定了产物。结果高度区域选择性地、以较好的收率得到了2位硫烷基取代产物。结论CH3ONa-CH3OH方法可以高度区域选择性地合成2位硫烷基取代产物,而K2CO3方法得到多取代烷基化产物。更多还原

【Abstract】 Aim To investigate the alkylation of 2-thiopyrimidine.Methods Treating the starting material 2-thiopyrimidine with chloromethyl ethers via a procedure of K2CO3 in DMF or with alkyl halide in CH3ONa-CH3OH at room temperature,to obtain the corresponding regioselective 2-S-allkyl pyrimidines.The products were determined by 1H NMR,2D NMR,IR and MS spectra.Results 2-S-alkyl-pyrimidines were regioselectively synthesized.Conclusion In different conditions with different alkyl halides,2-thiouracil could be converted into the corresponding 2-S-alkylpyrimidines regioselectively.更多还原