【摘要】 目的为确定中药复方桂枝汤中具有体温双向调节作用的物质基础,对其有效部位的化学成分进行了研究。方法用柱色谱分离,用理化性质及波谱方法鉴定结构。结果分离鉴定了6个化合物:芒柄花素(1),甘草素(2),异甘草素(3),6-姜醇(4),(3S,5S)-姜辣二醇(5),(3R,5S)-姜辣二醇(6)。结论以上化合物均为首次从桂枝汤对体温整合调节作用有效部位中得到,其中化合物1～3来源于中药甘草,化合物4～6来源于中药生姜。更多还原

【Abstract】 Aim To study the chemical constituents of the active fraction of Gui-Zhi decoction. Method The constituents were isolated and purified by column chromatography, and their structures were identified on the basis of spectral analysis. Result Six compounds, formononetin(1), liquiritigenin(2), isoliquiritigenin(3), 6-gingerol (4),(3S,5S)-1-(4-hydroxy-3-methoxyphenyl)-decane-3,5-diol (5), (3R,5S)-1-(4-hydroxy-3-methoxyphenyl) -decane -3,5-diol (6) were obtained. Conclusion All those compounds were isolated from the active fraction of Gui-Zhi decoction for the first time.更多还原