【摘要】 目的观察醛固酮拮抗剂在慢性心力衰竭治疗中的作用。方法选择符合慢性心力衰竭诊断标准的患者106例,随机分为治疗组(56例)和对照组(50例)。对照组应用慢性心衰的常规治疗;治疗组除应用常规治疗外每天服用螺内酯20～40mg,并且长期应用,定期测定血清钾和肝、肾功能,随访2年。结果治疗组56例因心衰恶化反复住院18例(占32%),死亡14例(占25%);对照组50例因心衰恶化反复住院26例(占52%),死亡21例(占42%)。经卡方检验两组对比,差异有统计学意义(P<0.05),治疗组再次住院率和死亡率明显低于对照组。结论慢性心力衰竭患者在常规治疗的基础上加用醛固酮拮抗剂,有助于改善心功能。更多还原

【Abstract】 Objective Observe the effect of aldosterone antagonists in the treatment of CHF.Methods Select 106 patients who accord with the diagnostic criteria of CHF,randomly divide the therapia group(56)and control group(50),the control group apply the conventional therapy of CHF,the therapia group apply spironolactone,20-40 mg/day and long-term application,except the conventional therapy.Periodically mensurate serum potassium,liver and renal function,follow-up two years.Results There were 18 repeated hospitalization cases(32%)and 14 death cases(25%)in the therapia group because of the deterioration of heart function,.however,26 repeated hospitalization cases(52%)and 21 death cases(42%)in the control group.There is significant difference in the rate of repeated hospitalization and death between the control group and the therapia group by chi squear test(P<0.05).The rate of repeated hospitalization and death in the therapia group was lower than that in the control group.Conclusion The application of aldosterone antagonists may improve heart function in the base of conventional therapy of CHF更多还原