【摘要】 目的了解血清游离脂肪酸(FFA)在高血压伴代谢综合征(MS)发病机制中的作用。方法选取高血压伴MS、单纯高血压、健康人群各50例。检测所有对象的FFA、体重指数(BMI)、腰臀比(WHR)和外周胰岛素敏感度(SI)等指标。结果①MS高血压病组的血清FFA高于单纯高血压组及健康对照组(P<0.05)。②血清FFA与SI呈负相关(r=-0.785,P<0.05),与BMI、WHR、收缩压(SBP)呈正相关(r分别为0.801、0.856,P<0.05)。结论高血压伴MS患者的高血清FFA与胰岛素抵抗并存,并有可能是引起高血压伴MS患者其他病理生理改变的主要机制。更多还原

【Abstract】 Objective To explore the role of free fatty acid (FFA) in the mechanism of hypertension accompanied metabolic syndrome. Methods One hundred and fifty objects were divided into three groups. They were hypertension with MS group, hypertension group, and health control group. Everyone in the study were tested the following parameters: serum FFA, BMI,WHR and SI. Results ⑴FFA concentration in serum of hypertension with MS patients was higher than those of the other two groups(P<0.05). ⑵There was negative correlation between serum FFA and SI(r=-0.785,P<0.05). While there was positive correlation between serum FFA and MBI, WHR and SP(The value of r were 0.801,0.856,0.872 respectively, all P<0.05). Conclusion There exits both high concentration FFA and insulin resistance in the patients who suffer from hypertension with MS. Maybe both of the two conditions are the main mechanism of the disease.更多还原