【摘要】 目的:观察安体舒通对慢性肾衰竭(CRF)并充血性心力衰竭(CHF)病人心功能的影响及安全性。方法:63例CKI合并NYHA心功能Ⅲl～Ⅳ级CHF住院患者,随机分为治疗组和对照组。对照组常规给以速尿、硝普钠、硝酸异山梨酯治疗;治疗组在常规治疗基础上加用安体舒通40mg/d,连续用药12个月。用药前后分别进行心功能、心脏多普勒超声检查,心率(HR)测定,定期测定血K+、Na+、Cl-、BUN、Cr,并做心电图及血压监测。结果:治疗组的疗效显著优于对照组(P<0.05),再住院及病死率较对照组显著减少(P<0.05);治疗组的心功能及心脏多普勒超声指标、HR均较对照组明显改善(P<0.05),血BUN、Cr浓度较对照组有显著改善(P<0.05),无严重副作用。结论:长期使用小剂量安体舒通治疗慢性肾衰竭并CHF安全有效。更多还原

【Abstract】 Objective:To observe the safety and the effects of antisterone on cardiac function in patients with chronic renal failure complicated with congestive heart failure.Methods:Sixty-three in-patents of chronic renal failure were enrolled, with cardiac function NYHAⅢ～Ⅳ grade. They were randomly divided into treatment group and control group. The patient of control group were given routinetherapy. The antisterone 40mg/d were given for twelve months continuously based on the routine treatment in patients of treatment group.After the treating,the cardiac function was compared with that before treating.Heart rate,ion concentrates(K+,Na+,Cl-),renal function,electrocardiogram and blood pressure were monitored.Results:In treatment group,the therapentic effect,cardiac function,heart rate and renal function were greatly improved(P<0.05),the rehospitalization rate and mortality were significantly decreased(P<0.05) compared with control group.Conclusion:It is safe and effective to treating CRF patients complicated with chronic heart failure with low dosage of antisterone for a long time.更多还原