【摘要】 预适应的概念发现以来,发现它是对抗心肌缺血的有效机制之一,经皮经腔冠脉成形术中反复球囊扩张是探讨预适应现象的最好的临床模型,也可以用于对预适应模拟药物作用的研究,如腺苷、尼可地尔、缓激肽、氨茶碱、硝酸甘油、尼索地平等。模拟预适应药物的应用可对抗心肌缺血,减少梗死面积,改善预后。更多还原

【Abstract】 Ischemic preconditioning is an effective mechanism against myocardial ischemic insults.Repetitive coronary occlusions by balloon inflation during elective percutaneous transluminal coronary angioplasty represent the best clinical model to discuss preconditioning phenomenon.It can also be used to discuss the effect of drugs inducing pharmacological preconditioning,such as adenosine,nicorandil,aminophylline,bradykinin,nisoldipine,and nitroglycerin.Preconditioning-mimetic drugs can be used against myocardial ischemia,reduce the scale of infarction and improve outcomes.更多还原