【摘要】 过氧化物酶体增殖物激活受体-γ的激活可通过抑制炎症反应、促进胆固醇的逆转运、调节胶原纤维合成/降解的失衡状态、改善血管内皮功能、改善纤维帽表面应力等多种途径去干预动脉粥样硬化易损斑块,并且它还可通过对易损血液的改善,减少血栓的形成,进而避免急性冠脉综合征的发生。因此,过氧化物酶体增殖物激活受体-γ激活剂可能成为稳定易损斑块的潜在药物,对防治急性冠脉综合征具有重要意义。更多还原

【Abstract】 The activation of peroxisome proliferator activated receptor γ (PPAR-γ) can interfere in vulnerable plaque by inhibiting inflammatory action, promoting the counter transport of cholesterol, accommodating the imbalance of collagenic composition/degradation, improving vascular endothelial function and the superfical stress of fibrous cap. Moreover, it can decrease thrombotic formation to avoid the incidence of acute coronary syndrome by improving vulnerable blood. Therefore, the activator of PPAR-γ may become a latent medicine to stabilize vulnerable plaque and important in the prevention and treatment of acute coronary syndrome.更多还原