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急性脑梗死患者血小板聚集、抗凝血酶和D二聚体的测定

The Detection of Plasma of Platelet Aggregation Antithrombin and D-dimmer in Acute Cerebral Infarction Patient

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【作者】 崔桂萍杨翠芝

【Author】 CUI Gui-ping, YANG Cui-zhi (Department of Laboratory , Tianjin Neuroscience Central Hospital, Tianjin 300060 China)

【机构】 天津市脑系科中心医院检验科石家庄市妇幼保健院检验科 天津 300060石家庄 050011

【摘要】 目的检测脑梗死患者的血小板聚集功能(PAgT)、抗凝血酶(AT)和D二聚体(D-D)的变化,同时比较其在治疗前后的变化。方法选用相应的仪器进行检测,PAgT采用比浊法,AT采用发色底物法,D-D采用免疫比浊法,对189例脑梗死患者组,与68例正常对照组进行上述三个项目的分析,同时对部分患者进行了治疗前、后的回顾性分析。结果脑梗死患者组AT为80.6±14.8%,明显低于对照组的100.4±14.2%(P<0.05);D-D和PAgT明显高于对照组(P<0.01);患者治疗前、后也有明显变化。结论可以将AT、D-D、PAgT作为脑梗死诊断、治疗监测的参号指标。

【Abstract】 Objective To measure the change of function of platelet aggregation test (PAgT), an-tithrombin (AT)and D-dimmer (D-D) ,and to compare the change fore and after treatment. Methods We a-dopt to turbidimetry for PAgT ,chromogenic bacteria for AT and immuroturbidimetry for D-D in appropriate instrument. Analysing three indexes in 189 patients with cerebral infarction during acute phase and 30 normal contrals, reviewing analyse part of patients in fore and after treatment. Results AT is 80.6±14.8% in the cerebral infarction group ,markedly lower than the controls (P<0.05). D-D and PAgT are higher than the controls (P<0.01) . There are obvious change in before and after therapy. Conclusion AT,D-D and PAgT can be used for reference indexes in diagnosis,therapy and detecting effect of cerebral infarction.

【基金】 国家自然科学基金资助项目(30171159)
  • 【文献出处】 血栓与止血学 ,Chinese Journal of Thrombosis and Hemostasis , 编辑部邮箱 ,2007年02期
  • 【分类号】R743.3
  • 【被引频次】2
  • 【下载频次】139
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