【摘要】 目的探讨牛磺酸对肾血管性高血压大鼠心肌肥厚及组织局部肾素-血管紧张素系统(RA S)的影响。方法采用两肾一夹型肾血管性高血压大鼠模型。所有大鼠被随机分为3组(每组20只):假手术对照组,高血压对照组和牛磺酸治疗组,于术后第5周开始给予牛磺酸50m g.kg-1.d-1。采用标准尾套法间接检测清醒大鼠血压。给药8周后,处死大鼠,分离左室心肌,检测左室重/体重比、心肌的血管紧张素Ⅱ含量(放射免疫法检测)和血管紧张素转换酶活性(分光光度计法检测)。结果与假手术组大鼠相比,未给药2K1C高血压大鼠血压明显升高,左室重/体重比增大,心肌的血管紧张素Ⅱ含量增加和血管紧张素转换酶活性均增高。应用牛磺酸治疗则明显抑制了肾动脉狭窄术后大鼠血压的升高,降低了2K1C高血压大鼠左室重/体重比、心肌的血管紧张素Ⅱ含量和血管紧张素转换酶活性。结论长疗程牛磺酸治疗可抑制肾性高血压大鼠心肌肥厚的发生,其机制可能与抑制心肌组织局部血管紧张素Ⅱ生成有关。更多还原

【Abstract】 Objective To investigate the role of taurine on cardial hypertrophy and local renin-angiotensin system in renovascular hypertensive rats.Methods The renovascular hypertension model was induced in rats by two-kidney-one-clip method.All the rats were randomly divided into three groups(n=20 per group):①the sham-operated control group,②the 2K1C renohypertensive control group,③the Tau group,the two-kidney-one-clip rats were treated with taurine at a dose of 50mg·kg-1·d-1 from 5th week after renal artery constriction.Indirect blood pressure was measured in conscious rats by the standard tail-cuff methods.After treatment with the drugs for 8 weeks,the rats were killed and the heart was removed to determine the left ventricle weight/ body weight(LVW/BW),myocardial angiotensin Ⅱ content by radioimmunoassay and angiotensin-converting enzyme activity by spectrophotometric method.Results Compared with the sham-operated control group,the untreated 2K1C renohypertensive rats exhibited an increase in blood pressure,LVW/BW myocardial angiotensin Ⅱ content and myocardial angiotensin-converting enzyme activity.Taurine significantly inhibited the increase in blood pressure,LVW/BW myocardial angiotensin Ⅱ content and myocardial angiotensin-converting enzyme activity of 2K1C renovascular hypertensive rats.Conclusion Long-term treatment with taurine could inhibit myocardial hypertrophy in renovascular hypertensive rats,which might be related to its inhibition of tissue angiotensin Ⅱ generation.更多还原