【摘要】 [目的]观察糖化血红蛋白(HbA1c)与非糖代谢紊乱发生的相关性。[方法]根据HbA1c将受检人群分为3组:①HbA1c﹤6.5%组;②6.5%≤HbA1c﹤7.5%组;③HbA1c≥7.5%组,对比分析3组发生高胆固醇血症、高甘油三酯血症、高尿酸血症、超重的情况并追踪观察1年。[结果]组②③高胆固醇血症、高甘油三酯血症、超重的发生率明显高于组①。其中高甘油三酯血症发生率在组③显著增高。1年后组③发生以上3项代谢紊乱的发生率明显高于组①。而高尿酸血症各时期的发生率在各组中均无差异。[结论]HbA1c持续维持在6.5%以下至少6个月以上,血脂代谢、脂肪代谢均可得到明显改善。超过7.5%则其发生率明显增高。HbA1c与高尿酸血症关系不明显。更多还原

【Abstract】 [Objective]To observe the correlation between glycosylated hemoglobin and non-carbohydrate metabolism disturbance.[Methods]The subjects were divided into three groups according to the level of HbA1c:① HbA1c﹤6.5% group ② 6.5%≤HbA1c﹤7.5% group ③ HbA1c﹥7.5% group.The incidence rates of hypercholesterolemia,hypertriglyceridemia,hyperuricemia and overweight in the three groups were compared and analyzed,and then metabolism disturbance in each group was observed after one year.[Results]The incidence rates of hypercholesterolemia,hypertriglyceridemia and overweight in groups of ② and ③ were obviously higher than those in group ①.Among them,the incidence of hypertriglyceridemia in group ③ was significantly higher.The one-year follow-up observation showed that the incidence of those three kinds of metabolism disturbances in group ③ was markedly higher than the group ①.But in the different period,there were no differences for the incidence of hyperuricemia in each group.[Conclusions]Dyslipidemia and fat metabolism can get improved obviously if glycosylated hemoglobin remained below 6.5% for more than six months.But if HbA1c remaines above 7.5%,the incidence of metabolism disturbances increases markedly.Glycosylated hemoglobin has no significant correlation with hyperuricemia.更多还原