【摘要】 [目的]探讨液基细胞学检测技术(TCT)在宫颈病变诊断中的应用价值。[方法]对在我院妇科门诊检查的4128例妇女行宫颈液基细胞学筛查,将诊断意义不明的不典型鳞状细胞(ASCUS)及以上病变均列为细胞阳性病例,并进行阴道镜下多点取材活检,以病理学结果为金标准,将细胞学结果与活检结果作对照分析。[结果]标本满意率为97.8%,发现细胞异常者455例,总检出率11.02%,其中癌(CA)6例(占0.15%),高度鳞状上皮内病变(HSIL)34例(0.82%),低度上皮内病变(LSIL)166例(4.02%),不除外高度鳞状上皮内病变的不典型鳞状细胞(ASC-H)25例(0.61%),不典型鳞状细胞(ASCUS)和不典型腺细胞(AGUS)共224(5.43%)。对其中400例进行病理检查,病理符合率分别是:CA100%;HSIL88.23%;LSIL56.30%;ASC-H29.16%;ASCUS+AGUS病理阳性率是13.93%。[结论]TCT是宫颈病变初筛的重要方法,结合阴道镜下活检可及早发现宫颈癌前病变。更多还原

【Abstract】 [Objective]To assess the value of thinprep liquid based cytological test(TCT)in diagnosis of cervical lesion.[Methods]4 128 cases of cervical lesions were detected with TCT.The samples of atypical squamous cells(ASC)and samples more severe than ASC lesions were classified into postive cytology,and then the cytological results of cervical biopsies were compared with pathological examination results.[Results]The satisfactory rate of TCT samples was 97.8%,and the postive rate of abnormal epithelial cells diagnosed by TCT was 11.02%. Among the 455 cases,there were 6 cases(0.15%)of CA,34 cases(0.82%)of HSIL,166 cases(4.02%)of LSIL,25 cases(0.61%)of ASC-H and 224(5.43%)of ASCUC and AGUS. 400 cases with postive cytologic results received pathological examination. The coincident rate of the results by two examination methods was 100% for CA,88.23% for HSIL,56.30% for LSIL,and 29.16% for ASC-H. The pathological positive rate of ASCUS and AGUS were 13.93%.[Conclusion]TCT is an useful method for cervical cancer screening,which can be adopted combined with biopsy under colposcopy to early discovering of pre-cancer diseases in time.更多还原