【摘要】 目的研究治疗早老性痴呆症药物石杉碱甲的鼻黏膜吸收特性。方法采用石杉碱甲进行大鼠鼻腔灌流实验,测定循环液中药物浓度。结果随着石杉碱甲的浓度增加(0.125~0.75mg/mL),其吸收速度呈线性增加(r=0.995)。在pH值5.5~7.5内,随pH值的升高,其吸收速度增加。结论石杉碱甲的鼻黏膜吸收良好,其吸收程度与药液的浓度和pH值有较好的相关性。更多还原

【Abstract】 OBJECTIVE To investigate the nasal absorption of huperzine A,which is a reversible acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease.METHODS In situ nasal recirculation method was used to estimate the nasal absorption rate constants of huperzine A in rats. RESULTS The absorption rate constants were increased with the increasing of the concentration(0.125-0.75mg/mL) and pH values(5.5~7.5)of huperzine A.CONCLUSION The nasal absorption of huperzine A was good and correlated with the concentration and pH.更多还原