【摘要】 目的对不同质子泵抑制剂对消化性溃疡出血的疗效及疗效-费用分析进行分析。方法83例消化性溃疡出血病人随机分为4组,分别给予:①静脉注射奥美拉唑40mg,q12h;②静脉注射奥美拉唑40mg,q12h,联合睡前一次静脉注射法莫替丁20mg;③静脉注射泮妥拉唑40mg,q12h;④静脉注射泮妥拉唑40mg,q12h,联合睡前一次静脉注射法莫替丁20mg。疗程均为5d。记录患者的止血时间、输血量、住院时间、转诊手术率、死亡率及住院总费用。结果4组患者的止血时间分别为1.3±1.0d、1.2±0.8d、1.3±0.8d、1.4±0.8d(P>0.05);输血量分别为1.7±2.8U、1.5±2.5U、1.6±2.4U、1.6±2.5U(P>0.05);再出血率为5.3%(1/19)、0、0、0(P>0.05);手术率和死亡率均为0;住院时间分别为10.6±7.4d、11.7±6.9d、12.9±5.9d、11.6±7.5d(P>0.05);住院总费用分别为7337.2±2133.1元、6908.6±2466.3元、7266.9±2993.1元、6646.3±2544.3元(P>0.05)。结论静脉注射奥美拉唑和泮妥拉唑均能有效治疗消化性溃疡出血,疗效及住院费用相当,夜间无需加用H2受体拮抗剂亦能达到同样疗效。更多还原

【Abstract】 Objective The aim of this study was to investigate the effectiveness and effect-cost in the treatment of patients with peptic ulcer bleeding by using proton pump inhibitor (PPI) omeprazole or pantoprazole. Methods Eighty-three patients with peptic ulcer bleeding were randomly divided into 4 groups. Patients in group A (19 cases) were treated by intravenous injection of 40 mg omeprazole (q12h for 5 days); Patients in group B (22 cases) received intravenous injection of 40 mg omeprazole (q12h), followed by the intravenous injection of 20 mg H2 receptor antagonist (H2RA) famotidine before sleep for five days. In group C (22 cases), the patients were given intravenous injection of 40 mg pantoprazole (q12h for 5 days); while in group D (20 cases), following intravenous injection 40 mg pantoprazole (q12h), the patients were treated by intravenous injection of 20 mg famotidine before sleep for 5 days. The haemorrhage time, rehaemorrhagia rate, operability and mortality rate, blood transfusion unit, hospital stay and cost were compared among four groups. Results The average time needed for hemostasis were 1.3 ± 1.0, 1.2 ± 0.8, 1.3 ± 0.8, 1.4 ± 0.8 days in group A, B, C and D, respectively. The rehaemorrhagia rate in group A was 5.3%, and was null in other three groups. Both the operability and the mortality rates of 4 groups were null. The blood transfusion units in group A, B, C and D were 1.7 ± 2.8, 1.5 ± 2.5, 1.6 ± 2.4 and 1.6 ± 2.5 U, respectively. The average time in ward in groups A, B, C and D were 10.6 ± 7.4, 11.7 ± 6.9, 12.9 ± 5.9, 11.6 ± 7.5 days; and the average costs were 7,337.2 ± 2,133.1, 6,908.6 ± 2,466.3, 7,266.9 ± 2,993.1 and 6,646.3 ± 2,544.3 RMB, respectively. No significant difference was found in all the parameters among the four groups. Conclusion The effectiveness of intravenous injection of omeprazole or pantoprazole twice daily on treatment of peptic ulcer bleeding is similar.更多还原