【摘要】 目的:观察马钱子药膏改善颈椎病患者周围神经压迫症状的临床效果,并与扶他林软膏进行对照。方法:将2002-06/2005-11到深圳市中医院门诊就诊的360例颈型、神经根型颈椎病患者随机分为治疗组185例和对照组175例,治疗组采用马钱子药膏,对照组采用扶他林软膏,均外用于颈项部,每天外搽3次,每次五六分钟,7d为1个疗程,持续治疗4周,每周观察记录1次。将颈项部疼痛、上肢放射痛、上肢麻木症状按轻重不同分别计为0,1,2,3分。同时参照2002年卫生部颁发的《中药新药临床研究指导原则》中关于颈椎病的诊断疗效标准判定疗效。结果:360例患者均进入结果分析。①治疗组治疗1,2,3,4周颈项痛、放射痛评分低于对照组(P<0.05或0.01)。治疗组治疗2,3,4周上肢麻木症状低于对照组(P<0.05或0.01)。对各症状的缓解主要体现在治疗的第1,2周,治疗第3,4周时效果趋于稳定,与治疗2周后的差异不明显。②治愈率和总有效率:治疗组高于对照组(41.6%,33.1%;92.4%,85.8%,P<0.05)。③治疗组有14例患者出现皮肤瘙痒症状,9例患者出现敷药部位的皮肤潮红,其中严重的有2例患者出现皮肤小水疱,对照组10例患者出现皮肤瘙痒症状,6例患者出现敷药部位的皮肤潮红,但经过正确的局部处理措施后,症状缓解。结论:马钱子药膏对颈项痛、上肢放射痛、上肢麻木等症状具有可靠的治疗效果,该药对上述症状的改善要优于扶他林软膏。更多还原

【Abstract】 AIM: To observe the clinical effect of extractum nucis vomicae on peripheral nerve pressure symptoms of cervical spondylopathy, and compare it with Voltaren ointment. METHODS: 360 patients with cervical spondylopathy in neck or nerve root diagnosed in Shenzhen Hospital of Traditional Chinese Medicine from June 2002 to November 2005 were selected and randomly divided into treatment group (n =185) and control group (n =175). The two groups were treated with extractum nucis vomicae and Voltaren, respectively by sticking on the neck, three times daily, five to six minutes every time, 7 days as one course of treatment for four weeks, and the effect was observed and recorded every week. The pain was scored 0, 1, 2 and 3 according to the degree of cervicodynia, brachialgia and numbness. Meanwhile, the curative effect was identified according to the criteria of the Guideline of New Traditional Chinese Medicine in Clinical Research for cervical spondylopathy issued by the Ministry of Health in 2002. RESULTS: All the 360 cases were involved in the result analysis. ①After treatment for 1, 2, 3 and 4 weeks, the scores of cervicodynia, and brachialgia of the treatment group were lower than those of the control group (P < 0.05 or 0.01). The numbness of the treatment group was ameliorated compared with the control group at 2, 3 and 4 weeks after treatment (P < 0.05 or 0.01). The symptoms were improved significantly at the first and second weeks, and the curative effect was stable at the third and fourth weeks, which was not remarkably different from the second week. ②The cure rate and total efficacy of the treatment group were higher than those of the control group (41.6%, 33.1%; 92.4%, 85.8%, P < 0.05). ③In the treatment group, there were 14 cases with cutaneous pruritus, 9 with erubesence at the affected part for sticking, and 2 with skin phlysis. In the control group, there were 10 cases with cutaneous pruritus, and 6 with erubesence at the affected part, which were relieved after right measures.CONCLUSION: As an external application drug, extractum nucis vomicae has a good effect on the peripheral nerve pressure symptoms of cervical spondylopathy, and its effect is superior to that of Voltaren.更多还原