【摘要】 目的:树突状细胞可借助其表面的一种模式识别受体Toll样受体对固有免疫及适应性免疫发挥免疫调节作用,Toll样受体是某些病原微生物借以逃逸机体免疫防御功能的靶分子,本文主要探讨Toll样受体的结构及功能、及其与病毒的相互作用。资料来源:应用计算机检索Pubmed 1980-01/2007-03期间有关树突状细胞表面Toll样受体及DC-SIGN受体结构、功能及相互关系文献,检索词“TLRs,DC-SIGN,antiviral immunity,HBV,HCV”,并限定文章语言种类为English。资料选择:选取树突状细胞表面Toll样受体和DC-SIGN及其抗感染免疫的相关文献,删除与Toll样受体或DC-SIGN抗感染免疫相关性不大的文献。资料提炼:共检索到65篇相关文献,33篇符合纳入标准。排除32篇文献中,12篇是与选取标准无关的研究,20篇属于重复研究。资料综合:目前已发现13种Toll样受体家族成员,其中11种表达于人类细胞。Toll样受体不同程度的表达于淋巴细胞、白细胞以及包括巨噬细胞和树突状细胞在内的单核吞噬细胞表面。巨噬细胞和树突状细胞等抗原提呈细胞上Toll样受体,构成一类独特的模式识别受体,是免疫应答的重要参与者,它能选择性识别侵入机体的病原微生物所携带的病原相关分子模式,诱导巨噬细胞和树突状细胞活化与成熟,产生细胞因子,引发针对病原微生物的适应性免疫应答。DC-SIGN与树突状细胞上Toll样受体之间有交叉联系,而这些交叉联系可导致免疫细胞活化或T细胞抑制。对于Toll样受体和DC-SIGN在人类肝炎病毒和艾滋病病毒-1感染过程中的作用了解尚浅。结论:Toll样受体在一些病毒感染过程中的作用还有待进一步研究。更多还原

【Abstract】 OBJECTIVE: Dendritic cells (DCs) regulate innate and adaptive immunity by one of the pattern recognition receptors, Toll-like receptors (TLRs). Some viruses may target TLRs to escape immune response. To explore the structure, function and interaction with viruses of TLRs.DATA SOURCES: We searched for articles about the structure, function and collaboration of receptors of TLRs and DC-SIGN on the surface of DCs published from January 1980 to March 2007 with the of ”TLRs,DC-SIGN,antiviral immunity,HBV,HCV” in Pubmed database in English. STUDY SELECTION: The articles closely related with TLRs, DC-SIGN and the mechanism of anti-infection immunity were selected. The articles unrelated with TLRs, DC-SIGN and the mechanism of anti-infection immunity were excluded. DATA EXTRACTION: Totally 65 relevant articles were retrieved and 33 of them met the inclusive criteria. A total of 12 unrelated articles and 20 ones with repetitive research were excluded. DATA SYNTHESIS: At present, 13 kinds of TLRs were found, of which 11 kinds were in human cells. TLRs were found in the surface of leukomonocyte, leukocyte and mononuclear phagocyte containing megalophage and DCs to different degrees. TLRs in macrophage and DCs were composed of a kind of receptor of pattern recognition and were the main participant of immunologic response. It could recognize selectively the relevant molecular mode of etiological agent in pathogenic microorganism, induce activation and maturity of macrophage and DCs, produce cytokines, and cause adaptive immunity response of pathogenic microorganism. DC-SIGN had cross association with TLRs in DCs, and these cross association could lead to activation of immunologic cells or T cell inhibition. Effects of TLRs and DC-SIGN in process of human hepatitis virus and AIDS related virus 1 infection were scarcely known. CONCLUSION: Effect of TLRs deserves further study in the process of some viral infection.更多还原