【摘要】 目的:探讨颈椎椎后肌肉组织Na+-K+-ATP酶活性变化与颈椎病的关系。资料来源:应用计算机检索PubMed1988-01/2004-12相关骨骼肌损伤与肌组织Na+-K+-ATP酶关系的文献,检索词“Na+-K+pump,Na+-K+-ATPase,muscle”,限定文献语言种类为English。同时计算机检索CNKI1990-01/2005-12相关Na+-K+-ATP酶与骨骼肌损伤的关系及颈椎病发病病因的文献,检索词“Na+-K+-ATP酶,骨骼肌,颈椎病病因”,限定文献语言种类为中文。资料选择:对资料进行初审,选取包括Na+-K+-ATP酶与肌组织损伤关系的文献,开始查找全文。纳入标准:Na+-K+-ATP酶活性变化与骨骼肌损伤密切相关的文献研究。排除标准:重复研究,Meta分析类文章。资料提炼:共检索到939篇关于Na+-K+-ATP酶与骨骼肌损伤相关方面的文献,最终纳入20篇符合标准的文献。资料综合:众多研究表明,Na+、K+与骨骼肌的兴奋、收缩、疲劳有密切关系,而Na+-K+-ATP酶又是调节细胞内外Na+、K+浓度必不可少的高分子蛋白,也就是说,骨骼肌一系列活动均离不开Na+-K+-ATP酶,Na+-K+-ATP酶活性变化与骨骼肌损伤是相互影响的。而强迫屈颈体位作为颈椎病发病的危险因素之一,可使颈椎椎后肌肉Na+-K+-ATP酶活性降低,酶活性降低致使肌细胞损伤,并最终导致骨骼肌损伤而发病。结论:以颈椎椎后肌肉酶活性的变化来阐释中医药对颈椎病确切疗效的相关研究未见,这有待于进一步研究,以充分展示中医药在颈椎病等相关疾病中的治疗优势。更多还原

【Abstract】 OBJECTIVE: To investigate the relationship between Na+-K+-ATPase activity in cervical vertebra muscular tissue and cervical syndrome. DATA SOURCES: A computer-based online search of PubMed database was undertaken to identify the articles about the relationship between skeletal muscle injury and Na+-K+-ATPase of the muscular tissues published in English between January 1988 and December 2004 with the keywords of "Na+-K+ pump, Na+-K+-ATPase, muscle". Meanwhile, we searched CNKI for the articles about the relationship between Na+-K+-ATPase and muscle injury, and the pathogenesis of cervical syndrome published in Chinese between January 1990 and December 2005 with the keywords of "Na+-K+-ATPase, skeletal muscle, the etiological factor of cervical syndrome" in Chinese. STUDY SELECTION: After the first check, the articles about the relationship between Na+-K+-ATPase and muscle injury were selected, then the full texts were looked up. Inclusive criteria: Articles about the close relationship between Na+-K+-ATPase activity and skeletal muscle injury. Exclusive criteria: Repetitive researches and Meta analysis articles. DATA EXTRACTION: 939 articles about the relationship between Na+-K+-ATPase and muscle injury were collected, and 20 articles were accorded with the research criteria. DATA SYNTHESIS: Many researches indicate that Na+ and K+ are closely related to muscular excitation, contraction and fatigue, and Na+-K+-ATPase acts as a kind of essential giant molecule protein that is to say the activities of skeletal muscle are dependent on Na+-K+-ATPase, and Na+-K+-ATPase activity changes and skeletal muscle injury are interactive. As one of the risk factors of cervical syndrome, the position of compulsive bowing head can reduce Na+-K+-ATPase activity, which could damage the muscle cells, and lead to the onset of cervical syndrome. CONCLUSION: The research about the effect of traditional Chinese medicine on treating cervical syndrome according to the muscular enzyme activity changes is seldom, so it needs further study to display the ascendancy of traditional Chinese medicine in curing cervical syndrome and other related diseases.更多还原