【摘要】 目的:总结目前心脏组织工程支架材料的发展现状,对窦房结组织工程的支架材料的选择提出意见,并展望未来支架材料的发展方向。资料来源:应用计算机检索PubMed数据库1995-01/2006-08的相关文章,检索词“tissue engineering,cardiac,scaffold-materials,sinuatrial-node”并限定文章语言种类为English。同时计算机检索中文科技期刊数据库(维普资讯)2000-01/2006-08的相关文章,检索词“组织工程,心脏,支架材料”限定文章语言种类为中文。资料选择:对资料进行初审,纳入标准:①组织工程窦房结的发展现状。②组织工程心脏的支架材料的发展现状和展望。排除标准:重复性研究。然后查找余下文章的全文,进一步判断目前支架材料的发展现状。资料提炼:共检索到文献132篇,其中外文心脏组织工程121篇,与支架材料有关的26篇;中文文献11篇,根据相应标准排除重复的文献,选取4篇应用。资料综合:在目前心脏组织工程中,研究主要集中于组织工程瓣膜和心肌,对于窦房结的组织工程的研究较少,在研究中采用的支架材料主要有3类:①合成的可降解高分子材料。②天然的可降解高分子材料。③去细胞基质材料。在研究中发现3种材料各有其优缺点,天然材料的组织相容性好,但是机械力学差,而合成的高分子材料则相反,去细胞基质的脱细胞处理方法仍在进一步改进中,因此,对于某一特定器官的组织工程,要根据其特定的需要来选择合适的支架材料。结论:天然的高分子材料有利于细胞的生长、增殖,其组织相容性好,很少发生免疫排斥反应,可以作为目前组织工程窦房结的支架材料。但未来根据窦房结细胞的特点,研制专门的支架材料是其发展方向。更多还原

【Abstract】 OBJECTIVE: To summarize current development of cardiac tissue engineering’s scaffold-materials, express opinions to the choice of the scaffold-materials in sinuatrial-node tissue engineering and look ahead the direction of the scaffold-materials. DATA SOURCES: The relevant articles between January 1995 and August 2006 were retrieval from PubMed by using the keywords of "tissue engineering, cardiac, scaffold-materials, sinuatrial-node" and restricting the language as English by computer. Meanwhile, the relevant articles were searched from database of Chinese Scientific and Technical Periodicals (Weipu) by imputing the key words of "tissue engineering, cardiac, scaffold-materials" in Chinese into computer. STUDY SELECTION: The literatures were screened primarily. Inclusive criteria:①the present development of sinuatrial-node tissue engineering;②the present development and prospect of the cardiac tissue engineering scaffold-materials. Exclusive criteria: Repetitive researches are excluded. Then the full texts from the rest articles were checked to further judge the present development of the scaffold-materials. DATA EXTRACTION: A total of 132 literatures were retrieved, including 121 extro-retrieved of cardiac tissue engineering and 26 literatures of them were about scaffold-materials, and 11 internal literatures and 4 literatures of them were collected for the application after those duplicate ones were excluded. DATA SYNTHESIS: Currently, the study of cardiac tissue engineering is concentrated on the tissue engineering valve and myocardial, while the research of sinuatrial-node tissue engineering is few. There are three types of scaffold-materials that have been researched:①the synthesized polymers that can be degraded;②natural polymers that can be degraded;③acellular matrix materials. Each material has its merits and shortcomings in current application, such as the histocompatibility of natural polymers is good but their mechanical property is weak, whereas the synthesized polymers is opposite. The method of acellular matrix is developing. Therefore, we choose the fit scaffold-materials according to particular demand of tissue. CONCLUSION: The natural polymers that are advantageous for the growth and propagation of the cells have good histocompatibility and seldom appear immunological rejection. So it can be the scaffold-materials of the current sinuatrial-node tissue engineering. According to the characteristics of the sinuatrial-node cell, the specialized scaffold materials are the direction of future study.更多还原