【摘要】 目的观察中药消渴保肾汤与贝那普利联合治疗早期糖尿病肾病的疗效。方法将78例早期糖尿病肾病患者随机分为3组各26例,3组均予胰岛素皮下注射控制血糖,在此基础上,A组加用贝那普利,B组加用消渴保肾汤和贝那普利,C组加用消渴保肾汤,疗程均为8周。观察治疗前后各组患者相关指标的变化。结果24h尿蛋白排泄率(UAER)3组治疗后均比治疗前显著下降(P<0.01),B组下降幅度优于A组和C组(P<0.05);空腹血糖(UPG)、餐后2h血糖(2h-PG)和糖化血红蛋白(HBA1c)3组治疗后均比治疗前显著下降(P<0.01);血压治疗后A、B组均比治疗前显著下降(P<0.01)。C组治疗后无显著性变化。结论消渴保肾汤与贝那普利联合治疗早期糖尿病肾病,在降低血压、血糖及糖化血红蛋白的同时,又可显著减少尿白蛋白的排出,优于单纯中药或西药治疗。更多还原

【Abstract】 Objective It is to observe the therapeutic effect of Xiaoke Baoshen Decoction(XBD) combined with Benazepril on early diabetic nephropathy(EDN).Methods 78 patients of EDN were divided into three groups randomly,with 26 patients in each group,and the blood glucose levels of all patients were controlled through giving insulin by subcutaneous injection on the base treatment above,patients in Group A were added with Benazepril,Group B with XBD and Benazepril,Group C with XBD respectively.The course of treatment for all was 8 weeks.The related indices of EDN before and after treatment were measured and compared.Results After treatment,the levels of 24 hours urinary albumin excretion rate(UAER) significantly decreased in 3 groups T and the decrement in Group B was more significant than that in the other two groups.The levels of FPG,2h-PG and HbA1c significantly decreased in all groups;the blood pressure significantly lowered after treatment in Group A and B,but unchanged in Group C.Conclusion XBD combined with Benazepril can not only decrease blood pressure,blood glucose and HbA1c,but also significantly decrease the UAER in treating EDN,with better efficacy than Chinese medicine or Western medicine alone.更多还原