【摘要】 目的观察α-干扰素与化疗联合治疗晚期鼻咽癌患者前后血清中IFNγ、TNFα、sFas基因水平变化。方法应用双抗体夹心ELISA法检测晚期鼻咽癌患者采用α-干扰素联合不同化疗方案治疗前后血清中IFNγ、TNFα、sFas基因水平。结果治疗前血清中IFNγ、TNFα和sFas水平均低于正常成人(P<0.05和0.01),治疗后三者水平均显著升高。结论α-干扰素与化疗联合治疗复发或转移的晚期鼻咽癌患者,可以提高患者血清中IFNγ、TNFα和Fas基因水平,增强患者的抗肿瘤免疫功能,促进肿瘤细胞凋亡。更多还原

【Abstract】 Objective It is to observe the changes of serum IFNγ,TNFα and sFas in patients with nasopharyngeal carcinoma in advanced stage before and after treatment with α-interferon combined with chemotherapy.Methods The levels of serum IFNγ,TNFα and sFas in the patients were determined by ELISA method before and after treatment with α-interferon combined with different chemotherapy.Results The levels of serum IFNγ,TNFα and sFas before treatment were all lower than those of healthy adults(P<0.05 or P<0.01),and they all obviously increased after treatment.Conclusion Treatment with α-interferon combined with chemotherapy can raise the levels of serum IFNγ,TNFα and sFas in the patients with nasopharyngeal carcinoma in advanced stage with relapse or metastasis,and improve the anti-tumor immunity function,and lead to the apoptosis of tumor cells.更多还原