【摘要】 目的:通过测定脑瘫患儿血清胰岛素样生长因子-1(IGF-1)、γ-氨基丁酸(GABA)、谷氨酸(GLU)的含量,探讨IGF-1、GABA、GLU在脑瘫发生发展过程中的作用机制。方法:应用放射免疫法检测脑瘫患儿血清IGF-1含量,应用高效液相色谱法测定脑瘫患儿血清中GLU、GABA含量。结果:1、脑瘫患儿血清IGF-1、GABA含量显著低于对照组(P<0.05),GLU含量显著高于对照组(P<0.05)。痉挛型和手足徐动型患儿血清IGF-1、GLU、GABA含量无显著差别(P>0.05)。2、脑瘫患儿血清GLU与GABA、IGF-1与GLU成负相关,GABA与IGF-1成正相关。结论:IGF-1、GLU、GABA均参与了CP病理生理过程,是反映脑损伤程度的生化指标,并可能参与CP的发病机制。更多还原

【Abstract】 Objective: To observe the levels of serum IGF-1、GABA and GLU before and after the therapy, then study the mechanism of IGF-1、GABA and GLU in the development of cerebral palsy. Methods:The levels of serum IGF-1 and neural transmitter were tested by radioimmunoassay and high performance liquid chromatography respectively. Results:1、The levels of IGF-1、GABA were significantly lower than those of the control group (P<0.05) whereas GLU were significantly higher than that of the control group(P<0.05). The levels of IGF-1 and neural transmitter were not obviously different between spasticity patients and athetosis patients (P>0.05). 2.Serum IGF-1 levels correlated positively with serum GABA level whereas the level of IGF-1 and GABA correlated negatively with the level of GLU in patients. Conclusion:IGF-1、GLU and GABA were all participated in the pathophysiology of cerebral palsy and may take part in the pathogenesis.更多还原