【摘要】 克隆了hDaxx全长的cDNA,并证实hDaxx与肽基脯氨酰异构酶Pin1之间存在相互作用,它们共定位于细胞核内。同时发现它们能够协同激活p53的转录活性,揭示Pin1可能在hDaxx调节细胞凋亡的过程中发挥了重要作用。更多还原

【Abstract】 In this paper we cloned hDaxx gene and showed the evidence that hDaxx interacted and co-localized with the peptidyl-prolyl isomerase Pin1. By using luciferase reporter assay,we found that hDaxx and Pin1 synergically stimulated the transcriptional activity of p53. This founding implicated the Pin1’s role in the regulation of hDaxx-modulated cell death and provided a potential approach to the understanding of the function of hDaxx.更多还原