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原花青素对SMMC-7721肿瘤细胞凋亡及其端粒酶活性的影响

Effect of proanthocyanidins on apoptosis and telomerase activity in SMMC-7721 human hepatocellular carcinoma

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【Author】 BAO Yong-hua~1,GUO Yong-chen~2,GUO Yan-jun~3,L Xue-shen~4,LIU Ying-qin~4,ZHAO Zhi-hui~1(1 Animal Husbandary and Veterinary College,Agronomy Department,Jilin University,Changchun,Jilin 130062 China;2 The First Affiliated Hospital Nuclear Medicine Department,Jiamusi University,Jiamusi,Heilongjiang 154002 China;3 The Ninetieth Secondary School in Changchun,Changchun,Jilin 130012,China;4 Department of Biology,Jiamusi University,Jiamusi,Heilongjiang 154002,China)

【机构】吉林大学农学部畜牧兽医学院；佳木斯大学附属第一医院核医学科；长春市九十中学西校；佳木斯大学生物教研室；吉林大学农学部畜牧兽医学院吉林长春130062；黑龙江佳木斯154002；吉林长春130012；吉林长春130062；

【摘要】采用M TT法、HE染色、DNA电泳、TUNEL法和TRAP法(端粒重复序列扩增法),研究原花青素对人肝癌细胞SMM C-7721株凋亡及端粒酶活性的影响,探讨了其抗癌机制。结果表明,原花青素可抑制SMM C-7721肿瘤细胞增殖,诱导细胞凋亡,降低细胞端粒酶活性。说明原花青素具有诱导肿瘤细胞凋亡和降低肿瘤细胞端粒酶活性2种抗肿瘤作用。更多还原

【Abstract】 To illustrate the effect of proanthocyanidins on apoptosis and telomerase activity in hepatocellular carcinoma as well as its antitumor mechanism,the effect of PC on SMMC-7721 cell line in vitro was studied by using MTT method,HE dying,DNA electrophoresis,TUNEL and TRAP(telomeric repeat amplification protocol).PC inhibited the growth of SMMC-7721 cell line by inducing apoptosis and down-regulating the telomerase activity.更多还原

【关键词】原花青素；肝癌细胞；细胞凋亡；端粒酶；
【Key words】 proanthocyanidins； hepatocellar carcinoma； apoptosis； telomerase；

【文献出处】西北农林科技大学学报(自然科学版) ,Journal of Northwest A & F University(Natural Science Edition) , 编辑部邮箱 ,2007年01期

【分类号】R735.7
【被引频次】24
【下载频次】527

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