【摘要】 以小白鼠为实验动物,采用饲料混毒法进行杀鼠活性测定。结果表明,曼陀罗不同生育期的杀鼠活性明显不同,9月份的样品杀鼠活性最强,其次为10月份,而8月份的样品杀鼠活性最弱,由此可以确定曼陀罗的最佳采样期为9月上旬。采用灌胃法测定曼陀罗对小鼠的毒性。结果表明,小鼠对曼陀罗的耐受量大于4 g.kg-1,小于16 g.kg-1,致死中量LD50=7.04 g.kg-1,95%置信区间为[5.75,8.62],回归方程为Y=0.8872+4.8535X。更多还原

【Abstract】 With Mus musculus as the experimental animal,the method of mixing pulverized plants directly into fodder was adopted to determine the killing rat activity.The results showed that significant differences in killing rat activities of Datura stramonium among different growing periods.The Datura stramonium collected in September was the best in killing rat activity, secondly was October and worst in August.So the early period the September is the optimum harvest period.The method of I.G was adopted to determine toxicity of Datura stramonium.The results showed that the maximum lethal dosage of Datura stramonium ranged between 4 g·kg-1 and 16 g·kg-1 to Mus musculus.The median lethal dosage was 7.04 g·kg-1 and the confidence interval range with 95 per cent was 5.75 to 8.62.The regression equation of LD50 was Y=0.887 2+4.853 5X.更多还原