【摘要】 目的研究脑胶质瘤环氧化酶-2(COX-2)和基质金属蛋白酶-2(MMP-2)的表达,探讨环氧化酶-2与胶质瘤侵袭性的关系。方法应用免疫组织化学染色方法检测68例脑胶质瘤COX-2与MMP-2蛋白的表达。结果COX-2在脑胶质瘤细胞中高表达,阳性表达率为61.8%,表达强度和病理分级呈正相关(χ2=14.24,P<0.01);MMP-2表达阳性率为72.1%,与COX-2的表达呈正相关性,差异有统计学意义(χ2=4.17,P<0.05)。结论COX-2在脑胶质瘤细胞中高表达,与病理分级密切相关,COX-2在胶质瘤侵袭中的作用与MMP-2的表达密切相关。更多还原

【Abstract】 Objectives To evaluate the expression of Cyclooxynenase-2(COX-2) in human glioma and explore its role in the development of gliomas.Methods In this experiment,we utilized immunohistochemistry technique to examine the expression of COX-2 and MMP-2 in glioma.Results The positive expression of COX-2 in human glioma was 61.8%,which was related with the histological grade of tumor.The difference among four grades tumor was statistically significant.Of the 68 cases,positive expression of MMP-2 was found in 49 cases(72.1%).Correlation in the exprssion of MMP-2 and COX-2 could be seen(χ2=4.17,P<0.05).Conclusions The expression of COX-2 at protein level is increased in human glioma and is correlated with the histological grade.The over expression of MMP-2 may be one of the pathways of COX-2 protein to contribute to the invasion and in the growth in human glioma.更多还原