【摘要】 目的探讨金纳多对抗脑出血后脑水肿形成的作用机制。方法选健康Wistar大鼠80只,雌雄不拘,随机分为4组,每组20只。采用立体定向注射方法,用微量注射器在右侧尾状核部位,注入50μL生理盐水(A、B组)或等量自体血红蛋白(C、D组)。术后A、C组给予50 g/L羧甲基纤维素钠溶液3 mL灌胃,B、D组给予等量羧甲基纤维素钠溶解均匀的金纳多(200 mg/kg)溶液灌胃,每日1次,持续3周。断头取脑,测定超氧化物歧化酶(SOD)、丙二醛(MDA)值及血红素氧合酶-1(HO-1)阳性细胞数。结果除A、B组比较无明显差异外,其余各组间SOD、MDA含量及HO-1阳性细胞数比较差异均有统计学意义(P<0.05)。结论金纳多可以抑制血红蛋白所引起的脑水肿。更多还原

【Abstract】 Objective To investigate the rivalry mechanism of ginkgo in rat brain edema after intracerebral hemorrhage.Methods Totally 80 healthy Wistar rats were divided into 4 groups randomly(20 rats in each group).Fifty microliters saline(group A and group B) or auto-hemoglobin(group C and group D) was infused into the right caudate nuclears using stereo tactic guidance.Groups A and C were lavaged 50 g/L carboxymethyl cellulose sodium solution of 3 mL,groups B and D were lavaged the same amount of ginkgo(200 mg/kg) solution dissolved by 50 g/L carboxymethyl cellulose sodium solution once a day for 3 weeks.All the rats were decapitated after raised for 3 weeks,and superoxide dismutase,malondialdehyde,and the number of hemeoxygenase-1(HO-1) positive cells in brains were assayed.Results The differences in SOD and MDA contents as well as HO-1 positive cell number between every two groups were significant(P<0.05) except group A and group B.Conclusion Ginkgo can inhibit brain edema after intracerebral hemorrhage caused by hemoglobin.更多还原