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黄芪注射液治疗糖尿病肾病的实验研究
Experimental study of theraputic effect of Milkvetch Injection on Diabetic Nephropathy
【摘要】 目的:探讨黄芪注射液对糖尿病肾病(DN)的作用。方法:链尿佐菌素(STZ)腹腔注射诱导建立DN大鼠模型,检测体重、血糖、内皮素(ET)和一氧化氮(NO)的变化。结果:DN大鼠NO含量降低,体重、血糖、ET含量明显升高;黄芪注射液能减少DN大鼠体重、血糖和ET含量,提高NO水平。结论:黄芪注射液具有保护肾脏的作用。
【Abstract】 Objective: To explore the effect of milkvetch injection on diabetic nephropathy(DN).Method: The rat model of DN was constructed by intraperitoneally injected streptozocin(STZ),and the body weight,blood glucose,endothelin(ET) and nitric oxide(NO) were measured.Results: It was showed that NO decreased significantly, while body weight,blood glucose,and ET increased significantly in DN rats,which indicated that milkvetch injection had the abilities mentioned above.Conclusion: Milkvetch injection is capable of protecting the kidney function.
【关键词】 黄芪;
糖尿病肾病;
一氧化氮;
内皮素;
大鼠;
【Key words】 Milkvetch; Diabetic nephropathy; Nitric oxide; Endothelin; Rat;
【Key words】 Milkvetch; Diabetic nephropathy; Nitric oxide; Endothelin; Rat;
【基金】 湖北省教育厅重点基金项目(NO:D200667002)
- 【文献出处】 微循环学杂志 ,Chinese Journal of Microcirculation , 编辑部邮箱 ,2007年01期
- 【分类号】R285.5
- 【被引频次】81
- 【下载频次】335