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血管内皮生长因子在门脉高压患者胃黏膜的表达
Expression of increased vascular endothelial growth factor in patients with portal hypertension
【摘要】 目的探讨血管内皮生长因子(VEGF)在肝硬化门脉高压(PHT)患者胃黏膜的表达及其在门脉高压性胃病(PHG)发病中的作用。方法分别采集PHG、PHT和正常对照组胃黏膜组织。应用免疫组化法检测胃黏膜VEGF蛋白的表达。PHG程度按改良的McMrmark’s分级由有经验的消化科医师盲法评估。结果PHG组(49.56%±12.26%)和PHT组(48.56%±12.23%)胃黏膜VEGF表达较正常对照组(5.11%±2.14%)显著性增高(P<0.05),但前两组间VEGF的表达无统计学差异(P>0.05)。VEGF阳性表达主要见于胃小凹颈部黏膜细胞浆内。VEGF与PHG积分呈显著性正相关(H=10.592,P<0.05)。结论肝硬化门脉高压患者胃黏膜组织VEGF表达增高。PHT胃黏膜淤血、缺氧与VEGF增加存在互动关系,VEGF在PHG发病过程中的作用可能是有限的。
【Abstract】 Objective To explore the expression of VEGF in gastric mucosa in patients with portal hypertension and the possible role of VEGF in portal hypertension gastropathy (PHG.) Methods The gastric mucosa specimens were obtained in protal hyperteasion patients with or without PHG,and in normal volunteer. The expression of VEGF in gastric mucosa was immumohistochemically determined. The degree of PHG was evaluated according to McMrmark’s. Results The percentage of gastric mucosa VEGF expression in the PHG (49.56±12.26%) and PHT without PHG (48.56±12.23%) was found to be higher than that in the control (5.11±2.14%) (P<0.05). There were no significance between PHG and PHT without PHG. The VEGF expression had a positive correlation with PHG score significantly(P<0.05). Conclusion The percentage of VEGF was higher in the PHT gastric mucosa. There was relationship between the hypoxic gastric mucosal state and the increase of VEGF in PHG. The effect of VEGF in pathogenesis of PHG was probably limited.
【Key words】 Vascular endothelial growth factor; Portal hypertension; Gastropathy; Gastric mucosa;
- 【文献出处】 胃肠病学和肝病学杂志 ,Chinese Journal of Gastroenterology and Hepatology , 编辑部邮箱 ,2007年01期
- 【分类号】R575.2
- 【被引频次】3
- 【下载频次】86