【摘要】 目的观察吗啡、东莨菪碱用于剖宫产术后硬膜外镇痛对母乳喂养新生儿神经生理功能的影响。方法50例行剖宫产术的产妇,随机分为对照组和观察组,每组25例。两组均采用连续硬膜外麻醉,对照组术后不用阿片类镇痛药,观察组采用硬膜外吗啡5 mg、东莨菪碱0．6 mg及布比卡因125 mg加生理盐水至100 ml持续自控镇痛。测定两组母乳喂养的新生儿术后24、48、72、96 h的神经适应能力评分(NACS)及观察组产妇术后镇痛的VAS评分。结果观察组VAS评分均小于1．3±1．43。两组新生儿于以上4个时点的NACS评分均在35分以上,两组之间比较差异无统计学意义。结论吗啡、东莨菪碱和布比卡因用于剖宫产术后硬膜外持续自控镇痛对母乳喂养的新生儿的神经行为能力无明显不良影响,应用于剖宫产术后镇痛是安全的。更多还原

【Abstract】 Objective To observe the effect of patient-controlled epidural analgesia (PCEA) with morphine, scopolamine and bupivacaine on breast-feeding neonatal neurological and adaptive capacity in post -cesarean section parturients. Methods Fifty post-cesarean section parturients were divided into control and observed groups on an average. The control group were served without any opioids analgesic and the observed group were administrated PCEA with morphine 5 mg, scopolamine 0.6 mg and bupivacaine 15 mg in normal saline 100 ml. The neonatal neurological and adaptive capacity scores (NACS) of breast-feeding newborns were measured at 24,48,72,% h after cesarean section in two groups. Visual analogue scales (VAS) of the parturients were recorded during PCEA. Results All VAS of PCEA with morphine, scopolamine and bupivacaine was less than 1.3±1.43 in parturients of observed group. Neonatal NACS were more than 35 at the above four measuring time points in both groups and no significant differences between two groups. Conclusion PCEA with morphine, scopolamine and bupivacaine is safe for breast-feeding newborns in post-cesarean section parturients.更多还原