【摘要】 目的观察时辰化疗在乳腺癌新辅助治疗中的近期疗效。方法70例乳腺癌病人随机分为时辰化疗组与常规化疗组,均采用CEF方案化疗,时辰化疗组:环磷酰胺(CTX)500 mg/m2,静脉推注,第1、8天,6 pm应用,表柔比星(E-ADM)80 mg/m2(分2天),静脉点滴,7 am应用,5-氟尿嘧啶(5-FU)500 mg/m2,第1、8天,静脉点滴4小时,1~5 am应用;常规化疗组:药物及剂量同时辰化疗组,但均在上午8 am~11 am之间应用。结果时辰化疗组与常规化疗组的总有效率及病理完全缓解率分别为:88.9%VS 61.8%(P<0.01);16.7%VS 0(P<0.05)。时辰化疗组的消化道反应、骨髓抑制及脱发均明显低于常规化疗组。结论CEF方案用于乳腺癌的新辅助治疗,时辰化疗与常规化疗比,具有疗效高、副作用低的优点,值得临床推广应用。更多还原

【Abstract】 Objective: To observe the effect Of chrono-chemotherapy on the new adjuvant treat of breast cancer.Methods: 70 cases were divided into chrono-chemotherapy group and routine-chemotherapy group randomly: in chronochemotherapy group,CTX500mg/m2,iv,d1、8,at 6pm,E-ADM80mg/m2,iv drip,at 7am,5-FU500mg/m2,d1、8,iv drip 4 hours,at 1-5am;in routine-chemotherapy group,the drug and the dosage were same as the chrono-chemotherapy group,at 8am-11am.Results: The total eefective rate and the physiology CR rate were 88.9% VS 61.8%(P<0.01),16.7% VS 0(P<0.05) respectively in the chrono-chemotherapy group and the routine-chemotherapy group.The cases of nausea,vomiting,bone marrow and alopecia in the chrono-chemotherapy group were lower than those of the routine-chemotherapy group.Conclusion: The chrono-chemotherapy has the good effect and also it has the low toxicity in the new adjuvant chemotherapy of breast cancer更多还原