【摘要】 目的:探讨不同ApoE基因型人群对适宜健骨运动处方防治原发性骨质疏松的敏感性,为制定基于基因多态性的个性化运动处方提供理论依据。方法:74名原发性骨质疏松患者按ApoE基因型随机分为ε2组、ε3组和ε4组,进行为期3个月的有氧及抗阻运动训练,双能X线骨密度吸收仪(DXA)测定运动前后骨矿含量、腰椎(L2～4)及髋部骨密度(BMD)的变化。结果:ε4组BMC运动前后的变化率高于ε2组(P<0.05);L2～4BMD运动前后无显著变化;ε4组髋部BMD运动前后的变化率显著高于ε2组(P<0.05)。结论:运动疗法防治原发性骨质疏松的效果受ApoE基因多态性的影响,其中ε4型人群通过运动疗法防治骨质疏松的效果较好。更多还原

【Abstract】 Objective: To explore the interaction of exercise intervention and ApoE gene polymorphisms on BMD,which will provide a theoretic evidence for establishing special and personal exercise prescriptions to prevent and cure postmenopausal osteoporosis.Methods: 74 middle-to-aged subjects with osteoporosis,whose ApoE gene HhaΙ polymorphisms were defined using polymerase chain reaction(PCR) and restriction fragment length polymorphism(RFLP) techniques,were selected to participate 12 weeks of bone-invigorating exercise.During pre-and post-exercise,we measured bone mineral content(BMC),lumbar vertebra(L2~4) and femur BMD by Dual x-ray absorptiometry(DXA).Results: The increase(%change) of both BMC and hip BMD in ε4 group after 12 weeks of training was greater than that in ε2 group,but the percentage change of lumbar vertebra(L2~4) BMD of each group was not significant.Conclusions: ApoE gene polymorphisms may modulate the effect of exercise on BMD.Apoε4 allele group may benefit more from the effect of exercise on BMD than those with Apoε2,Apoε3.更多还原