【摘要】 目的探讨通过介入封堵实验动物的左前降支,建立规范化的室壁瘤模型的新方法。方法在DSA下对13只家猪置入“WYW”冠状动脉栓塞装置,封堵LAD第一对角支开口处远端。术中及术后观测心电图、血清心肌酶谱、心肌核素显像、超声心动图、心血管造影等指标。结果1只动物在术前死于麻醉意外,6只在封堵过程中死于心室颤动,其余6只均存活。术后各项检查结果显示其前降支闭塞,左室前壁、心尖部及部分右室前壁心肌梗死,并出现运动异常,平均梗死区域占室壁面积为(30.8±0.5)%。结论应用“WYW”介入栓塞法建立的室壁瘤模型较接近临床病理生理演变过程,效果确切可靠、创伤小、器械设备要求不高,可望为冠心病的治疗和研究提供一种可靠的动物模型。更多还原

【Abstract】 Objective To explore a new interventional approach for developing an animal ventricular aneurysm animal model.Methods After anesthesia,balloon catheter with "WYW" stent was put into 13 pigs’ left anterior descending coronary artery.The balloon was dilated and the stent was positioned into the distal point of the first diagonal branch to obstruct the artery.During and after the operation,electrocardiogram was monitored and recorded.Cardiac troponin,emission computed tomography,echocardiography,angiography,morphological and histological,were also investigated to confirm the presence of acute myocardial infarction and ventricular aneurysm.Results Six animals successfully gave rise to ventricular aneurysm in all 13 pigs.The mean size of myocardial infection of the aneurysms was(30.8±0.5)%.Conclusion The new approach is able to develop an animal ventricular aneurysm model which is more minimal-invasive and similar to the patient.更多还原