【摘要】 目的观察国产左旋卡尼汀(雷卡)对老年糖尿病合并冠心病患者血浆游离肉碱、游离脂肪酸浓度的影响。方法根据冠状动脉造影结果将老年患者(>60岁)分为单纯糖尿病组(DM)和糖尿病合并冠心病组(DM+CD),测定两组患者血浆肉碱和游离脂肪酸浓度,并观察卡尼汀对上述指标的影响。结果与DM组比较,DM+CD组患者体内存在肉碱缺乏(74.38±11.45 vs 48.17±15.13);给予卡尼汀治疗2周后,DM+CD组患者血浆游离脂肪酸浓度显著下降(664±65 vs 1296±137),血浆肉碱浓度显著升高(116.58±31.45 vs 48.17±15.13),P<0.01。结论老年糖尿病合并冠心病患者体内存在肉碱缺乏,雷卡可有效提高患者体内肉碱水平。更多还原

【Abstract】 Objective To study the change of free carnitine(FC) level in aged(>60)type-Ⅱ diabetic patients with coronary heart disease(CHD) and the influence of L-carintine() on plasma free carnitine and free fatty acid(FFA).Methods Plasma FC and FFA were measured in 20 type-Ⅱ diabetic patients(group DM) and 20 type-Ⅱ diabetic patients with CHD(group DM+CD)before and after they received L-CN(3.0 g/d) intravenous infusion for 14 d.Results Compared with group DM,group DM+CD had lower FC(74.38±11.45 vs 48.17±15.13 μmol/L).After L-CN treatment FC increased(116.58±31.45 vs 48.17±15.13 μmol./L)and FFA decreased(664±65 vs 1296±137 μmol/L)in group DM+CD.Conclusion It suggests that FC deficiency may exist in aged type-II diabetic patients with CHD,and it is beneficial for type-II diabetic patients with CHD to receive LCN treatment.更多还原