【摘要】 为了对雷公藤药物进行减毒增效,采用超临界流体萃取技术对雷公藤有效成分的萃取进行了研究．实验以有效成分雷公藤甲素、雷公藤生物总碱以及毒性成分雷公藤红素的收率以及在浸膏中的质量分数为指标,分别对夹带剂种类与组成、萃取温度、萃取压力、静态浸泡时间等因素进行了考察．结果表明,当75％乙醇水溶液为夹带剂,萃取温度为43℃,萃取压力为25 MPa,静态萃取时间为3 h,进行超临界流体萃取时,有利于有效成分雷公藤甲素以及生物总碱的萃取．所得结果与传统方法进行比较,超临界流体萃取雷公藤甲素收率是传统方法的3．49倍．超临界流体萃取可以有效萃出主要有效成分雷公藤甲素．更多还原

【Abstract】 Supercritical fluids extraction (SFE) of the effective components from tripterygium wilfordii Hook. f. ( T. wilfordii) was explored for its toxin-reducing and effect-increasing. Taking the yield and content of triptolide , total alkaloids and tripterine as indexes, some influence factors such as co-solvent variety and its composition, the extraction temperature, pressure and the static soak time were studied. The experimental results show that when 75% ethanol as co-solvent is used for 3 h of static soak time under the extraction temperature of 43℃and pressure of 25 MPa, the yield of the main active component triptolide is 3.49 times as much as that of the traditional method. The main active component triptolide can be effectively extracted by SFE.更多还原