【摘要】 目的观察安心改善心肌缺血的作用。方法采用垂体后叶素(PIT)所致大鼠心肌缺血模型,监测标准Ⅱ导联心电图;小鼠腹腔注射PIT,测定血清脂质过氧化产物丙二醛(MDA)含量及超氧化物歧化酶(SOD)以及磷酸肌酸激酶(CK)和乳酸脱氢酶(LDH)的活性。结果安心能明显缓解PIT所致大鼠心电图T波的改变。在PIT所致小鼠心肌缺血模型中,安心能增加SOD的活性,降低血清LDH,CK,MDA的活性。结论安心对PIT所致的心肌缺血有较好的保护作用。更多还原

【Abstract】 Objective To observe protective effects of Anxin,a complex of Chinese medicine,on myocardial ischemic injury. Methods The electrocardiograph(ECG) was observed in myocardial ischemia rats induced by pituitrin(PIT) through lingual vein;the contents of MDA,SOD,CK and LDH in serum were assayed,respectively,in myocardial ischemia mice which pituitrin was peritoneal injected.Results High(2.8 g/kg),medium(1.4 g/kg) dose of Anxin could obviously relieve the ECG changes caused by pituitrin-induced myocardial ischemia in rats.The threshold dose of Anxin(4 g/kg,2 g/kg)decreased CK,LDH,MDA production and increased SOD activity in the serum of mice.Conclusion Anxin possesses the protective effect on myocardial ischemia induced by PIT.更多还原