【摘要】 目的:探讨提高孕7-9周药物流产的有效性药物剂量。方法:因非意愿妊娠要求终止早孕的孕7-9周妇女256例,随机分为二组,A组(109例)和B组(147例)。d1-2分别分次口服米非司酮150mg或200mg;d3口服米索前列醇600μg,4h后无论胚囊是否排出,均加服米索400μg。结果:A组完全流产率为91.2%,B组为92.5%,P>0.05。药物流产后阴道出血时间、出血量、转经时间、经期及经量二组均无统计学差异。结论:两种方法的完全流产率均达到90%以上,200mg米非司酮配伍米索前列醇,可能减少孕囊排出时的出血量,对孕7-9周的妇女不失为一种安全的药物流产手段。更多还原

【Abstract】 Objective: To compare the efficacy and side effects of mifepristone 150 mg and 200 mg followedby misoprostol 600 μg plus 400 μg in medical termination of 7-9 weeks gestation. Methods: A total of 109 casestook mifepristone 150 mg orally, 50 mg in the morning and 25 mg 12 h later for 2 d (group A), and 147 casestook mifepristone 200 mg orally, 50 mg in the morning and 50 mg 12 h later for 2 d (group B). Misoprostol wasgiven orally in d 3, 600 μg in the morning and 400 μg 4 h later. Results: There were no significant differences betweentwo groups in the rates of complete abortion (91.2% in group A vs 92.5% in group B). The duration and amount ofvaginal bleeding and the recovery of the first menstruation after abortion were similar in two groups.Conclusion: The results suggest that these two protocols are effective and safe for termination of 7-9 weeksgestation.更多还原