【摘要】 目的：探讨男性不育与外周血白细胞雄激素受体表达的关系。方法：根据精液分析及睾丸活检病理检查结果,将67例男性不育症患者分成少精子症组（n=21）、弱精子症组（n=15）、阻塞性无精子症组（n=14）和非阻塞性无精子症组（n=17）,采用放射配体结合分析法检测不育症患者外周血白细胞雄激素受体（AR）,同时采用放射免疫法检测血清睾酮（T）和雌二醇（E₂）水平,并以22例正常生育男性为对照。结果：外周血白细胞AR含量少精子症组、弱精子症组、阻塞性无精子症组与对照组比,均无统计学差异（P＞0．05）；非阻塞性无精子症组（782±98）与对照组（913±104）相比,差异有统计学意义（P＜0．01）。男性不育症各组与对照组相比,E₂和T水平差异均无统计学意义（P＞0．05）；而男性不育症患者精子密度与白细胞AR含量呈正相关（r=0．233,P=0．010）。结论：一部分男子不育的发生、发展过程可能与AR表达下调有密切关系。更多还原

【Abstract】 Objective:To investigate the associations between expression of androgen receptor and the occurrence of male infertility.Methods:According to semen and testis pathological analysis,67 case of infertile patients were divided into oligozoospermic group（n=21）,asthenozoospermic group（n=15）,obstructive azoospermic group（n=14）,non-obstructive azoospermic group（n=17）.Specific binding capacity of androgen receptor （AR） in peripheral leukocytes was measured by radioligand binding assays in 67 infertile males and 22 controls,and levels of testosterone（T） and estradiol（E₂） were also detected by radioimmunassay.Results:Exception of non-obstructive azoospermic group,the binding capacity of AR in the control had no significant difference with those in other infertile groups （P＞0.05） when there was no significant difference between all the patients and normal control in the levels of T and E₂ （P＞0.05）.The binding capacity of AR in non-obstructive azoospermic group was lower than that in the control （P＜0.01）.AR contents were 782±98 sites/cell and 913±104 sites/cell in the non-obstructive azoospermic group and in the control,respectively.Further,there were positive correlations between the sperm density and the binding capacity of AR in infertile males（r=0.233,P=0.010）.Conclusion:The changes of AR may play an important role in the process of pathogenesis of male infertility and have applicable value in the diagnosis and typing of male infertility.更多还原