【摘要】 目的:评价血清超敏C-反应蛋白(hs-CRP)对急性冠脉综合征(ACS)预后的判断价值。方法:选择我院ACS患者150例,其中不稳定型心绞痛72例(UAP组),急性心肌梗死78例(AMI组),另选稳定型心绞痛患者68例(SAP组)和健康人80例(健康对照组),UAP患者又按Braunwald分为Ⅰ级20例,Ⅱ级23例,Ⅲ级29例,观察4组研究对象hs-CRP水平及UAPⅠ、Ⅱ、Ⅲ级患者的hs-CRP水平,并观察随访期间不良心血管事件发生率。结果:4组研究对象hs-CRP间差异均有非常显著性意义(P<0.01),两两比较各组间差异亦有显著性意义(P<0.05);UAP组Ⅰ、Ⅱ、Ⅲ级患者hs-CRP间差异有非常显著性意义(P<0.01),且Ⅰ级与Ⅲ级,Ⅱ级与Ⅲ级间差异均有非常显著性意义(P<0.01);hs-CRP升高组(>3mg/L)ACS患者随访期间不良心血管事件发生率明显高于hs-CRP正常组(≤3mg/L)(发生率为46.1%比12.5%,P<0.01)。结论:hs-CRP可作为ACS危险分层和预后的预测因子,hs-CRP水平升高对判断ACS患者预后有较好的预测价值。更多还原

【Abstract】 Objective To evaluate the value of high sensitivity C-reactive protein (hs-CRP) for predicting the prognosis of patients with acute coronary syndrome (ACS). Methods Seventy-two patients with unstable angina pectoris (20 with Braunwald classification Ⅰ,23 with Ⅱ,and 39 with Ⅲ; UAP),78 with acute myocardial infarction (AMI),68 with stable angina pectoris (SAP),and 80 healthy control subjects were included in this study. The hs-CRP levels were compared among the four groups and the data were statistically analyzed. The incidence of adverse cardiovascular events was assessed during follow-up. Results The hs-CRP levels in UAP group and AMI group were significantly higher than those in SAP group and control group (P < 0.01). In UAP group,there was a significant difference in hs-CPR between the patients with classification I and those with Ⅱ or between those with Ⅱ and Ⅲ(P < 0.01). The incidence of adverse cardiovascular events was higher in the patients with an increase in hs-CRP ( > 3 mg/L) than in those with normal hs-CRP (≤3 mg/L) (46.1% vs 12.5%,P < 0.01). Conclusion The increase in hs-CRP is of a better value in predicting the prognosis of the patients with ACS.更多还原