【摘要】 目的了解云南省某高校大学生乙型肝炎疫苗接种后乙型肝炎表面抗体(抗-HBs)产生状况,与其他报告比较以评价其免疫效果,探讨相关影响因素,找出合适的策略。方法采用试剂盒ELISA法测定血清中抗-HBs。结果390名检测对象抗-HBs总阳性率79.74%;男生和女生抗-HBs阳性率分别为76.47%、80.24%;汉族学生和少数民族学生抗-HBs阳性率分别为80.97%、75%;2000级、2001级、2002级、2003级抗-HBs阳性率分别为47.54%、83.5%、88.64%、84.04%。结论本次检测的390名大学生抗-HBs阳性率与普遍报道的基本接近,男生和女生、汉族和少数民族学生抗-HBs阳性率差异无显著性,不同年度接种疫苗的学生抗-HBs阳性率存在差异;应在接种前和接种过程中尽量避免人为因素干扰以提高抗-HBs阳性率;接种疫苗后应进行抗-HBs检测以确定免疫是否有效及随后的加强免疫时间确定。更多还原

【Abstract】 Objective To know the status of antibody after Hepatitis B vaccine Vaccination of some university students of Yunnan province and to compare with other reports on immune effects and to estimate correlative factor so that to find out strategy.Methods To detect sera antibody to HBsAg with ELISA kit.Results The positive percents are 79.74% in 309 sera samples.the positive percents of schoolboy and schoolgirl are 76.47% and 80.24%respectively. the positive percents of Han nationality and minority are 80.97% and 75% respectively. the positive percents of students of grade 2000-2003 are 47.54%,83.5%,88.64% and 84.04%.Conclusion The positive percents of anti-HBs in 309 sera are near to reported. the positive percents of schoolboy and schoolgirl are no distinct difference but the difference in students of different grade. In order to improve the positive percents of anti-HBs We should avoid man-made disturbance in vaccination and detect the anti-HBs to ensure the best vaccination time of next dose .更多还原